Critical parameters for the stability of cefquinome sulfate in aqueous solutions and solid phase
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چکیده
منابع مشابه
Stability of Cefpirome Sulfate in Aqueous Solutions.
The influence of pH on the stability of cefpirome sulfate was investigated in the pH range of 0.44 - 13.00. The degradation of cefpirome sulfate as a result of hydrolysis was a pseudo-first-order reaction. General acid-base hydrolysis of cefpirome sulfate was not observed. In the solutions of hydrochloric acid, sodium hydroxide, acetate, borate and phosphate buffer, k(obs) = k(pH) because speci...
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A novel and sensitive stability-indicating RP-HPLC method for the quantitative determination of cefquinome sulfate has been developed. Chromatographic separation and quantitative determination were performed using a high-performance liquid chromatograph with UV detection. As the stationary phase a LiChroCART RP-18 column (5 microm particle size, 125 mm x 4 mm, Merck, Darmstadt, Germany) was use...
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15 صفحه اولStability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions
Stability of ceftiofur sodium and cefquinome sulphate in intravenous solutions was studied. Chromatographic separation and quantitative determination were performed by using a high-performance liquid chromatography with UV-DAD detection. During the stability study, poly(vinylchloride) minibags were filled with a solution containing 5 mg of ceftiofur sodium or cefquinome sulphate and diluted to ...
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Cefquinome Sulfate (CS) is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species. However, Cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. So, in this study, to increase Cefquinome Sulfate biological half-life, a novel C...
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ژورنال
عنوان ژورنال: Reaction Kinetics, Mechanisms and Catalysis
سال: 2017
ISSN: 1878-5190,1878-5204
DOI: 10.1007/s11144-017-1257-0